The winners of the all-Oxford clash, to be played on October 17th, will then go to Brize Norton in the quarter-finals on November 21st.
Witney-based Tower Hill make their competition debut with a home tie against Headington Athletic.
The semi-finals are scheduled for February 20th 2011, with the final on April 17th.
Oxfordshire Cup 1st Round Draw (October 17th 2010)
Tower Hill v Headington Athletic
Oxford United v Oxford City
Banbury United v Henley Town
Chinnor v Bardwell
Quarter-Finals (November 21st 2010)
Launton v Chinnor or Bardwell
Tower Hill or Headington Athletic v Mansfield Road
Banbury United or Henley Town v Carterton
Brize Norton v Oxford United or Oxford City
